Typically, acetylation of histone tails leads to ________.
Question: Typically, acetylation of histone tails leads to ________.
Histone acetylation typically leads to an open or relaxed chromatin conformation, allowing for easier access of transcription factors and RNA polymerase to the DNA, and thus promoting gene expression.
The N-terminal tails of histone proteins protrude out of the nucleosome and are subject to various post-translational modifications, including acetylation. Acetylation of lysine residues on histone tails neutralizes their positive charge, reducing their affinity for the negatively charged DNA. This weakens the interaction between histones and DNA, resulting in a more open chromatin conformation.
Acetylation also creates binding sites for proteins that contain bromodomains, which can recruit additional factors that promote transcription, including chromatin remodeling complexes, histone modifying enzymes, and transcriptional activators. Together, these factors can further promote the formation of a transcriptionally active chromatin structure.
Therefore, histone acetylation is generally associated with gene activation and increased transcription.
Rjwala is your freely Ai Social Learning Platform. here our team solve your academic problems daily.
0 Komentar
Post a Comment