Who is responsible for replacing new bone cells?
Question: Who is responsible for replacing new bone cells?
Bone cells are constantly being replaced by new bone cells through a process called bone remodeling. Bone remodeling is carried out by two main types of cells: osteoblasts and osteoclasts. Osteoblasts are bone cells that secrete new bone matrix, which is a complex framework of collagen, proteins and calcium salts that supports the structure and function of bone tissue. Osteoclasts are bone cells that resorb old or damaged bone matrix and dissolve its minerals, making room for new bone tissue to form. Together, these cells maintain the homeostasis of the bone tissue by regulating its shape, strength and mineral composition.
There are also different types of stem cells that are responsible for new bone growth under different conditions. For example, researchers have found that bone marrow SSCs (skeletal stem cells) repair smaller, stabilized bone injuries and are responsible for normal bone growth during adulthood. On the other hand, periosteal SSCs (stem cells from the outer layer of the bone) are mainly responsible for repairing larger, unstabilized injuries like fractures.
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