A scientist notices that a cancer cell line fails to die when he adds an inducer of apoptosis to his culture of cells. which hypothesis could explain why the cells fail to die?

Question: A scientist notices that a cancer cell line fails to die when he adds an inducer of apoptosis to his culture of cells. which hypothesis could explain why the cells fail to die?

Apoptosis is a process of programmed cell death that occurs in multicellular organisms. It is essential for maintaining tissue homeostasis and eliminating damaged or unwanted cells. However, some cancer cells can evade apoptosis and become resistant to various treatments. A possible hypothesis to explain why a cancer cell line fails to die when exposed to an inducer of apoptosis is that the cell line has mutations in the genes that regulate the apoptotic pathway. For example, the cell line may have overexpressed anti-apoptotic proteins, such as Bcl-2, that prevent the activation of caspases, the enzymes that execute apoptosis. Alternatively, the cell line may have inactivated pro-apoptotic proteins, such as p53, that sense DNA damage and trigger apoptosis. These mutations may confer a survival advantage to the cancer cells and allow them to proliferate uncontrollably.

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